The Caco-2 cell monolayer model can be conveniently used for the purpose of absorption screening (Zhou et al., 2012), particularly as an in vitro model of the intestinal barrier. This monolayer has been extensively used to determine the transport kinetics and metabolism of dietary compounds in vitro. As such, the Caco-2 monolayer is a useful in vitro screening tool for drug discovery and mechanistic studies.

Main Researcher: Dr. Leow Soon Sen
Email: ssleow@mpob.gov.my